KrosFlo® KR2i TFF System for volumes of 1 mL to 10 L(R&D Scale Bioprocessing)

產品介紹:

桌上型全自動切向流濃縮透析系統,符合cGMP要求,為量產等級的先導測試與線性放大準備之機型,適用Hollow fiber與TFF cassette,組合彈性、操作簡易且自動達到濃縮與透析倍率後停機;全數值與實驗參數自動記錄在Excel中;平板電腦觸控控制並可將電腦遠端移至BSC外使用。

規格訊息:

KrosFlo® Research IIi Tangential Flow Filtration System (KR2i)

Fully integrated Tangential Flow Filtration System for processing R&D volumes Product Searches
 

系統數位化+軟體整合=再現性!!

精準的TMP=>100%通透率=>延長HF column使用率!

KR2i 絕對是您在"濃縮分離程序"上最佳的選擇!!

 

 

 

Brochure使用手冊

Krosflo Research IIi全自動濃縮與分離系統是小規模研發到先導型生產階段的理想選擇,整套系統能符合FDA確效(Validation)相關要求。樣品處理量為1 ml - 10 L,根據實驗數值能直接從小體積放大到量產等級。此系統搭配數位壓力監測器和背壓調節閥,能收集訊號並傳至蠕動幫浦,自動演算出TMP值並進行調控,使條件從頭到尾維持一致性,也提供過壓警報和安全停機功能,有助於維持膜的完整性,提高膜的使用壽命。藉由KF Comm 資料擷取軟體,可將數據傳至電腦紀錄,即時紀錄實驗。此系統還搭配天秤(Permeate Scales)、快速接頭、可調式支架與固定夾等實驗所需配件,無須擔憂系統銜接架設問題,能提供最高效率、高再現性的切向流過濾實驗。

 

-  為高效率之切向流系統

-  有數位壓力監測,自動演算TMP值

-  有背壓調節閥

-  能監測過濾速率

-  擁有安全停機功能

-  高再現性

-  符合cGMP需求

-  系統可直接放大,從實驗室等級至量產等級

-  資料輸出功能,能即時監控整個實驗數據並全部匯整到Excel中

 

 

The KR2i is designed to interface with a number of Auxiliary Scales and Pumps to enable automated process controls. There are instructions for each of the 6 automated process controls:

 

C: concentration 濃縮模式

D: dialysis 透析模式(換液模式)

CF: constant feeding 持續饋料模式

 

C Modesimply concentrate the process solution but may also be used to automate flushing the hollow fiber filter before use

 

C/D Modeconcentrate and then diafilter the process solution in succession

 

C/D/C Modecan diafilter the process solution with two different buffers in succession before concentrating the process solution a second time

 

C/D/D/C Modecan diafilter the process solution with two different buffers in succession before concentrating the process solution a second time

 

CFC Modemaintain a constant feed weight while concentrating the solution

 

CF/D/C Modemaintain a constant feed weight while concentrating the solution, then wash the solution with a buffer during diafiltration, and then concentrate the process solution further

 

 

根據六種自動化模式組合濃縮、透析、補液自由搭配微電腦幫浦與停機秤,到達條件即自動執行下一步指令

 

濃縮模式-單幫浦單秤 (左圖); 濃縮透析補液模式 2-3幫浦雙秤(右圖)

 

        

 

12種條件記錄
 
  • 時間 (Time)
  • 入口端壓力 (Inlet pressure)
  • 回流端壓力 (Retentate pressure)
  • 過濾端壓力 (Permeate pressure)
  • 入口流速 (Feed flow rate)
  • 幫浦轉速 (Pump RPM)
  • 幫浦模式 (Pump mode)
  • 過濾流速 (Permeate flow rate)
  • 提醒 (Notes, alarm, process status, functions)
  • 過濾透析流速 (Diafiltration flow rate)
  • 樣品重量 (Feed scale weight)
  • 過濾端重量 (Permeate scale weight)

 

 

自動計算8種參數
 

  • 穿膜壓力 (Transmembrane pressure; TMP)
  • 過濾流速 (Permeate flow rate)
  • 回流流速 (Retentate flow rate)
  • 流量 (Flux)
  • 壓降 (Pressure drop; ΔP
  • 容積通過量 (Volumetric throughput; VT)
  • 濃縮因子 (Concentration factor)
  • 剪切力 (Shear)

 

 

微電腦蠕動幫浦-標準配備幫浦頭,適用六種矽膠管,隨意搭配,靈活運用

 

轉速範圍: 0.1~600 rpm

流量範圍: 0.06~2300 ml/min

 

Tubing size L/S 13 L/S 14 L/S 16 L/S 25 L/S 17 L/S 18
Inner diameter 0.8 mm (0.03") 1.6 mm (0.06") 3.1 mm (0.12") 4.8 mm (0.19") 6.4 mm (0.25") 7.9 mm (0.31")
Hose barb size 1.6 mm (1/16") 1.6 mm (1/16") 3.2 mm (1/8") 4.8 mm (3/16") 6.4 mm (1/4") 9.5 mm (3/8")
Flow range
(approximate)
0.06 to 36 ml/min 0.21 to 130 ml/min 0.8 to 480 ml/min 1.7 to 1000 ml/min 2.8 to 1700 ml/min 3.8 to 2300 ml/min

 

 

 

 

 

自動背壓調節裝置,隨時調節壓力至最佳狀態

 

 

 

 

 

 

1.KrosFlo® Research 2i Pump Drive w/ Integrated Pressure Monitor 

 

2.KrosFlo KF Comm Software Suite (on USB) 

 

3.Auxiliary Component Octopus Cable 

 

4.Pressure Transducer Cable 

 

5.Power Supply Cable 

 

6.KrosFlo® Research II Easy-Load Pump Head 

 

 

 

 

 

 

 

KONDUiT add-on monitor
即時監測電導率,UV和溫度

Conductivity: 0.1 to 100 mS/cm

Temperature: 0-70 °
Pressure: Up to 75 psi (5 bar)
 
 
 
 
 
 
 

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